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FIG. 8. Hybrid state model for the translational elongation cycle (128). tRNA-binding sites on the 50S and 30S subunits are represented by the upper and lower rectangles, respectively. The 50S subunit harbors A (aminoacyl), P (peptidyl), and E (exit) sites, and the 30S subunit has only A and P sites. tRNAs are represented by vertical bars, and amino acids are represented by small circles. mRNA is represented as a line bound to the 30S subunit. The directional movement of the acylated and deacylated tRNAs through the ribosome, catalyzed by elongation factors EFTu and EFG, during the translational cycle is indicated, as are the proposed stimulation of the peptidyl transferase by EFP and tRNA ejection by RbbA. PT, peptidyl transfer.
