Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

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Microbiology and Molecular Biology Reviews, June 1999, p. 349-404, Vol. 63, No. 2
1092-2172/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

Frédéric Pâques and James E. Haber^*

Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110

The budding yeast Saccharomyces cerevisiae has been the principal organism used in experiments to examine genetic recombinationin eukaryotes. Studies over the past decade have shown that meioticrecombination and probably most mitotic recombination arise fromthe repair of double-strand breaks (DSBs). There are multiplepathways by which such DSBs can be repaired, including severalhomologous recombination pathways and still other nonhomologousmechanisms. Our understanding has also been greatly enriched bythe characterization of many proteins involved in recombinationand by insights that link aspects of DNA repair to chromosomereplication. New molecular models of DSB-induced gene conversionare presented. This review encompasses these different aspectsof DSB-induced recombination in Saccharomyces and attempts torelate genetic, molecular biological, and biochemical studiesof the processes of DNA repair andrecombination.

^* Corresponding author. Mailing address: Rosenstiel Center, Brandeis University, Mailstop 029, Waltham, MA 02454-9110. Phone:(781) 736-2462. Fax: (781) 736-2405. E-mail: haber{at}hydra.rose.brandeis.edu.

Microbiology and Molecular Biology Reviews, June 1999, p. 349-404, Vol. 63, No. 2
1092-2172/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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